Postmortem molecular screening in unexplained sudden death

Postmortem molecular screening in unexplained sudden death.

OBJECTIVES We examined the prevalence of defects in arrhythmia-related candidate genes among patients with unexplained sudden cardiac death (SCD). BACKGROUND Patients with unexplained sudden death may constitute up to 5% of overall SCD cases. For such patients, systematic postmortem genetic analysis of archived tissue, using a candidate gene approach, may identify etiologies of SCD. METHODS...

Molecular Autopsy in Unexplained Sudden Death

Sudden death (SD) is defined as an unexpected natural death in apparently healthy individuals that takes place during the first hour after onset of symptoms [1]. There is a large proportion of SD that remains unresolved, without a definitive diagnosis [2]. This fact is due to medical reports are not accessible in all cases, no autopsy is performed or the cause of death given after autopsy is no...

Molecular Autopsy in Unexplained Sudden Death

Sudden death (SD) is defined as an unexpected natural death in apparently healthy individuals that takes place during the first hour after onset of symptoms [1]. There is a large proportion of SD that remains unresolved, without a definitive diagnosis [2]. This fact is due to medical reports are not accessible in all cases, no autopsy is performed or the cause of death given after autopsy is no...

Explaining sudden unexplained death.

Postmortem long QT syndrome genetic testing for sudden unexplained death in the young.

OBJECTIVES This study sought to determine the spectrum and prevalence of long QT syndrome (LQTS)-associated mutations in a large cohort of autopsy-negative sudden unexplained death (SUD). BACKGROUND Potentially heritable arrhythmia syndromes may explain a significant proportion of SUD in the young. Here, comprehensive postmortem LQTS genetic testing was performed in a cohort of SUD cases. M...